The only problem I have with that is Nanomachines doing amazing things have been with the franchise since the start. Plus the surreal being explained by science was already done before, for example with Fortune.Well, make no mistake, the meme is funny. "Nanomachines son!" is sadly the culmination of all the disappointment felt by MGS4, because nearly all the interesting, surreal stuff in the series was answered with them, like Vamp's immortality. It's just...sad, and ruined a bit of the charm the franchise had :c But hey, at least we can laugh about it ;p
But I digress, back to the Vs Match: to answer Z218, Raiden's dash in MGR auto blocks bullets so Blue Rose shouldn't be much of a problem. It's the Devil Bringer and Yamato that are the main issue.