Pretty sure it was confirmed to be Nero, but they also promised more role for Dante.
He’s vital to the series.
Nero is Shadow, the anti-hero turned hero who is trying to atone for the mistakes of his past organisation, and who turns out to have a surprising connection to the villain of the new game (assuming Vergil is legit in this game no deception).
@Foxtrot94 they could introduce a new lead but thats gonna be an uphill battle.
Probably but imo it's doable if they manage to bring closure to Dante like DMC5 is said to aim to do. At that point I can see Nero taking over and people being more accepting of him.