He's bound to say that. He's a game designer. All game designers say that, because that is originally how they get into the profession, but that's NOT how they survive in it. To say that creative and artistic integrity outweighs the carrot (or the stick) of money is a vocational lie. CAPCOM handed DMC over to them to redesign the whole thing in order to attract a wider audience— which equals more money— to get more money. This is CAPCOM we're talking about who sanctioned this, fabled for their love of recycling old material again and again and again, and why would they even bother not doing that with DMC unless they saw significant financial incentive in taking it to the West to pander to the gargantuan market there? And to choose a relatively cheap and lesser-known Brit studio to handle it? Money. Money money money.
Something good might come out of it, but I am not for a second going to believe this is some 'labour of love' of NT's over the Quest for Bigger Profits in the background as decreed by CAPCOM. I have relatives in the gaming industry, and I know doing whatever you feel like there because you're an 'artist', is, ironically, just not how it works. From his own personal standpoint, sure, he'll have failed if he stops being artistic and creative if that's what he got into the industry for. But he is surely subject to plenty of conditions and considerations over and above 'art', without doubt, and money (or translate that to 'the market' and "how can we make this so it will sell/compete?") is usually the biggest.
The changes they appear to have made on the original material to create DmC all fall in line with what's currently popular and accepted in the West, from Dante's looks, to dress, to language and behaviour, to even the changes to the canon to make more sense to Westerners. What you're seeing is the creative 'skin' over a product that has been specifically tweaked to sell to Westerners and appeal to them as well as compete with the current market trends. SOME creativity, and a whole LOT of pandering, in other words.
Others might not see it, but making it 'grittier' and 'more believable' is a dead giveaway, as is the new look they have chosen for Dante, as was the confession "he's just not cool enough" (for people over here now), necessitating his complete redesign to look like a rather generic male Westerner.