I for one would be the first to pre-order it...
On a more serious note, I don't really know how the public would receive it.
I would personally find it a much appreciated change, especially if the storyline and character development are made a primary focus. I think NT's reboot was a good improvement from the classic series, which is more flamboyant, but it doesen't really go in depth in the description of the characters. DmC did a better job, in this regard, especially for Vergil, who is not shown as just the stereotypical who is power-hungry just for the sake of being power-hungry because we need to fit in a boss somewhere (the infamous line "Without strength you cannot protect anything" is not really much to go by).
But I recognize that many gamers loved Devil May Cry not because of the storyline, nor for its well developed characters. Its strengths were mainly in the gameplay.
We must also remember that DmC suffered a lot for being a change from the old series. I fear that another change could possibly alienate another part of the potential public.
It is a bet, I think: there would be good reasons to like this Vergil spinoff you're suggesting, but I honestly don't know how many fans (not counting Vergil fans, obviously) would endorse it.