I'm gonna be that one guy to say that I think it's better if Vergil doesn't come back in a next DMC game (assuming it takes place after DMC1 and thus after 3 too).
One, it would make his defeat in DMC3 and 1 meaningful so it doesn't feel like Vergil keeps reappearing because the plot needs him to stay alive. Two, the story would have to find new ways to make itself interesting instead of relying on Vergil to do that. Sure the Dante/Vergil dynamic is interesting enough, but we already went through that in the third game. Instead a potential DMC5 could try to find new ways to build on its lore, most notably by talking about the elephant in the room: Sparda.
One, it would make his defeat in DMC3 and 1 meaningful so it doesn't feel like Vergil keeps reappearing because the plot needs him to stay alive. Two, the story would have to find new ways to make itself interesting instead of relying on Vergil to do that. Sure the Dante/Vergil dynamic is interesting enough, but we already went through that in the third game. Instead a potential DMC5 could try to find new ways to build on its lore, most notably by talking about the elephant in the room: Sparda.