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DMC
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Aliens vs Predator
The videogames and the comics are where this franchise shines. Time to make another game, Fox.
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Prince of Persia
Yep, the reboot. The Sands of Time trilogy closed and it was fantastic (I'm pretending The Forgotten Sands doesn't exist). The 2008 reboot was promising and with tons of potential. Keep the fantastic art style, and improve the gameplay. Get rid of stupid 1 vs 1 fights to begin with, and... give us the possibility to die!
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F.E.A.R.
After the abomination I consider F.3.A.R. to be, and F.E.A.R. Online, for the love of GOD, make another F.E.A.R. game with actual horror again, like the first 2 chapters. Wrap it up making this franchise justice.
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Neverwinter Nights
Obsidian improved some gameplay elements in NWN2, but imo, they partially destroyed the beautiful atmosphere of the first game. Bioware needs to come back to the franchise and finally develop a new title.
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Quake
Really? One of the franchises that made the history of the FPS genre - heck, the history of gaming even - doesn't get a sequel after Quake 4? I want a Quake 5. OR an Enemy Territory: Quake Wars 2.
I watched an interview to Vin Diesel some time ago where he said his studio was beginning to work on a new Riddick title. I think he mentioned it would be multiplayer focused.