The only Devil May Cry game that I really didn't like was the second one. I thought Capcom dropped the ball on that one. Especially when you compared it to how great the 1st one was. But, I felt Capcom bounced back pretty well with the 3rd one. I feel that even though DmC didn't get the super huge numbers they initially wanted, they can still do a sequel.
As far as Devil May Cry 5...I was a huge fan of Devil May Cry 4 and felt they could have made a follow up on the back of that one. A Nero spin-off, bring back Virgil, etc. I still hope they do a follow up to DMC 4. And since I'm hooked on DmC now, wouldn't mind a DmC 2 as well