If DMC is going to be continued, I'd prefer it if they stick to Dante. He already got shafted in DMC4 in favour of Nero. Plus, we still haven't reached the end of Dante's story. There are a lot more adventures I'd like to see him do, and we still haven't seen a conclusion to what happened after the end of DMC2. They should at least finish that before dropping Dante and starting games with just Nero in.
On the other hand, a game with Nero as the sole protagonist would be good to develop his character considering they wasted a lot of his potential in DMC4. But I wouldn't like this Nero game to come right after DMC4. I'd prefer DMC5 first with only Dante as a playable character.