Despite the success of the original Devil May Cry, the sequel was not created by Hideki Kamiya or Capcom Production Studio 4. The first notice Kamiya's team was given about any sort of sequel occurred during localization of Devil May Cry in North America and Europe, a move which greatly surprised Kamiya. Since the game's release, Kamiya has expressed disappointment that he was not called on by his superiors at Capcom to direct Devil May Cry 2.
Instead, the sequel was granted to Capcom Production Studio 1 and Hideaki Itsuno, the team responsible for Capcom VS SNK 2. According to producer Tsuyoshi Tanaka, the thrust of the design was to make Devil May Cry 2 bigger than its predecessor; Tanaka estimated that the game's environments were approximately nine times as large as the first. The emphasis on puzzles was also downplayed, with the camera system revamped to allow for better action scenes. Changes from the first game were influenced by surveys distributed by the development team, allowing them to patch any areas identified as weak by the people surveyed. The addition of Lucia as a playable character was a response to player complaints that Trish was not playable in the first Devil May Cry.