Not really, if you pay attention to Dante's movements, facial expressions - he doesn't really want to kill anyone, really. Especially as the series progressed from DMC1 to DMC5. It was during DMC5, he started to have some sort of empathy towards humans. He's more of a demon hunter, not by choice, but by necessity. He starts out in DMC1, not giving a **** about anyone, but as the story progressed, he started to be urgent in cleansing earth of demons. Humans in general can't compete against Dante or Vergil, so they're not really the main focus of DMC series. It was DMC4, where the story has elements of this idea - especially towards the end of the game. They did it again in DMC5, but instead of the villain wanting more power to glorify his "god" complex (yes, that's basically the story in DMC4) to dominate people on the ground... In DMC5, you actually have a boss that wants the society's "bloodline" by sacrifice (killing humans).
Now, if you pay attention to the DmC: Devil May Cry alternate reality storyline, you'd know that you wouldn't know if Arius and Sanctus don't look like demons. They look like humans, but once they're ****ed, they're gonna change into demon form. Mundus in DmC: Devil May Cry, you wouldn't think he's a demon, until you see the cutscenes and final battle. But if you played DMC1 and DMC3, you'd already know he's a demon. You even fight his spawn. However, I will omit Sanctus from this idea of "oh, he's a demon." Uh, no. Sanctus is a lousy excuse for a boss in DMC4. That's where DMC4 falls apart story-wise.