No, his canon is no more relevant, but both games and DMC4 novel confirm Dante ages like a human being.( We can even compare his aging with Lady's)
Dante's Age (Yes, Another One)
- Thread starter The 4th Snake
- Start date
Guess it depends on how much of his canon counts on Itsuno & Co.'s agenda.
Yet in DMC2 it is supposed to be years from DMC1 but dante is only a little older and if he goes demon form which he does he is practically unaging.So surely every time he dt's he revitalises his cells.
DMC2 was originally supposed to be set closer to DMC1, but then it became embarrassing enough that they pushed its story in far future so they don't have to deal with it so soon... or ever, hence why Dante doesn't look so old.
Gameplay-wise, dt indeed makes Dante heal, so one can take it as really revitalizing his cells story-wise as well. However, Dante spends more time in human form, which I guess does a lousier job or something.
Which is why I am saying thay when he dt's that he probably reverses his aging on a cellular level which is why he always looks so young, he may age like a human but he can slow that down by dt'ing which he does.