Dante may be stronger, more veratile and have more moves, but Nero is still much more efficient (=less skill required for the same results).
Charged Shot 3 + Max Act and then EX Streak + DT do avoid getting hit is just the perfect tactic against pretty much any enemy in dmc4. Load your gun while using EX Streak w/ Max Act and use DT if an enemy is about to hit you. You can do an insane amount of damage with almost no effort. I just started Bloody Palace to see how far you can get with this tactic and I ended up finishing BP without even too much effort. Whenever my health was to low I just spammed EX Streak and Charged Shot 3 and nothing could hit me. I also had 8 minutes left when I was finished, so it seems to be quite fast too.
Charged Shot 3 + Max Act and then EX Streak + DT do avoid getting hit is just the perfect tactic against pretty much any enemy in dmc4. Load your gun while using EX Streak w/ Max Act and use DT if an enemy is about to hit you. You can do an insane amount of damage with almost no effort. I just started Bloody Palace to see how far you can get with this tactic and I ended up finishing BP without even too much effort. Whenever my health was to low I just spammed EX Streak and Charged Shot 3 and nothing could hit me. I also had 8 minutes left when I was finished, so it seems to be quite fast too.