It's certainly become way more ambiguous since Gru, Nell and the events of the novel now did happen but with the events of that taking place just before the events of DMC1 and Vergil showing up years before it can no longer be Gilver who did all of it. Gru's daughters are also at an odd age since if they are as young as it says in the novel they are only 10 to 12 years older than their novel counterparts and since the novel takes place before Dante gets his guns, it's how he got his guns, it means that it couldn't have been 10 to 12 years since DMC3, which also makes no sense since Patty is 18 now and was around 10 to, at most, 13 in the anime. The timeline for DMC is even more convoluted now that before. At Least as far as we know. With all the changes they might actually have a cohesive and cemented way the events went down but we're kind of in the dark about it. At least that's my hope because otherwise they did all this fanservice just to make everything rather convoluted.