While I would like a DMC5 (hell even a DmC2.....although this might be a controversial statement to say...as long as NT isn't involved) I would prefer another Rival's School.
A. While Devil May Cry have been neglected for like what a few years (maybe less if you include the Definitive and Special Edition) there are plenty of other Capcom classics that need have been neglacted for decades and games Itsuno himself made (Rival Schools being one)
B. We need more 3D fighters that aren't Tekken and DOA (like LITERALLY those are the only 3D fighters that ever come out anymore......that are good or worthwhile). Lets hope Capcom keeps it 3D.
C. I kind of prefer games like Power Stone, Star Gladiator, and Rival Schools a little bit more than Devil May Cry as a whole.
D. We need more games that aren't "so serious" (Heath Ledger Joker, Dark Knight). I don't see how Capcom can make a silly fighting game set in high school serious. Just camp it up.
E. There are so much cool ideas I personally would like to see. This game has more potential than a new DMC because most things that they do will probably alienate any part of the fan base (see DmC) and Devil May Cry has built a stigma that a Devil May Cry needs to be a certain way or it has to progress in a certain way whereas Rival Schools can mostly do what it wants and no one will care since it doesn't have a dedicated fanbase who dictate how it should and shouldn't be just people who played the games in the past and enjoyed them for being fun (in both gameplay and style). As long as they maintain the spirit of being fun they can alter the combat system (make it like Tekken although it played more like a 2D fighter made 3D like the Naruto Clash of Ninja Games).
F. A modern day take on the game and its high school setting has potential for fun to be had. The old 2 games were old school anime high school but this was a time Capcom was more abrasive of their anime cliches and stereotypes nowadays they try to appeal to as much people as possible so I would like to see both high school anime/Japanese cliches and western high school cliches in a story that is a mix of the Crows Zero movies and a high school drama....or it could just turn into Kill la Kill (minus the ridiculous second half). Plus if it has a campaign mode where you can wander through the school and join clubs and each character embodies a club or a faculty/dept (like most of them did in the original) that would be cool but a normal fighter with a straight forward story mode is fine as long as.......
G. I get to see Tiffany's boobs and Natsu's beautiful thighs in glorious 1080p-4K 60fps modern day graphics and resolution.
H. If Itsuno is making it Dante can always make a cameo (but we'll probably get Sakura instead). I mean I would like to see Dante beat up some teenagers or a DmC Dante-esque character makes an apperance (a promiscuous, edgy troubled British transfer student and past Rival Schools were open to use non-Japanese or foreigners in its Japanese high school setting like a black priest who is tired of the student's **** and Tiffany).
I. Did I mention Tiffany's rack and Natsu's legs......I need to make those pretty clear.