Mega Man Collection 2 has apparently just been leaked. Doubt it counts as a 'major title' but this is Capcom so you never know. I'll keep my fingers crossed for a new DMC!
It's not that. Only new titles would be considered major titles, and only stuff like RE7, DR4, MvC: I, SFV, MHX". DMC, RE2 Remake, or a new Dragon's Dogma, Dino Crisis, Onimusha, Darkstalkers, Mega Man on the scale of those titles would be "major titles".
It will probably be revealed at E3 then. Monster hunter has been huge lately though so i'll try not getting my hopes to high...
Sales expectations are down in Japan from 3.5m last year to 2.75m this year, so if it's Monster Hunter they're expecting to do less than MHXX and Stories despite launching both during the last fiscal year. Mainline MH titles, XX excepted, usually do 3m+ within a few weeks. Additionally, expected sales for US is up from 4.3m to 4.7m, and in Europe from 2.2m to 2.65. They launched RE7 and DR4 last FY, but despite that they're expecting increased sales.