Azrael: The Punishment. The Angel of death, Dante's maternal grandfather. Defeating him in a quick sparring match gets you Reaper, a black angelic scythe.
"J": A mysterious Nephillim trapped in Purgatory. He trains Dante to access his true power. Gives Dante the Nephillim weapon Redeemer, a Sword stylized after a cross that wields great power. Seems to hold humans in the highest regard, calling them his "favorite species".
Jack Kira: Son of one of the seven princes, A demonic destroyer. Jack is a powerful cambion who was trained to kill Dante. He wields Clawed Gauntlets and Greaves, and fights more like an animal than a man.
Gabe Ryan Ellakin: Son of Gabriel, an Angelic Assassin, trained by The Seven Archangels to kill Nephillim. The only one he has never defeated is "J". He refers to "J" as "Immanuel", Dante as "Zamiel", and Vergil as "Apollyn." Gabe had a crush on Eva, and hates Sparda, blaming him for her death. Gabe wields twin Scimitars like his father.
Emmanuel: The Knight. The current Leader of the Seven Archangels. Insanely powerful, to near God-like levels. He believes that humanity is so corrupt that they should be destroyed. He also hates the cambions and Powers (half angels), but deems Gabe a necessary evil.
Metatron: The Scribe. An Archangel, the only non warrior. He hates what the others have become, and helps Dante AND Vergil in secret.
Gabriel: The Messenger. A fast Archangel, father of Gabe. He's one of the oldest Archangels, the brother or Michael and Sariel, who would become Lucifer. He struggles to remain loyal to Emmanuel, and balance his sense of morals with his sense of duty.
Barachiel: The Thunder. A lightning infused Archangel who uses a spear, Gungnir. He remains loyal to the leader of the Archangels, not to the ideals.
Uriel: The Light. Archangel #5. A light infused angel who can teleport at will. He's arrogant, condescending, and more than a little xenophobic.
Saraqael: The Fire. An smart, if demented Archangel. He cares not for heaven, earth or hell, wishing only to spread the flames.
Raphael: The Healer. The quintessential combat medic. Raphael cares for his charges, but lacks self respect. He's also incredibly trusting, believing all of his allies lies.
Leviathan: Demon of envy. A Massive serpentine demon, one of the Seven Princes.
Amon: Demon of Wrath. A wolflike snake tailed demon.
Mammon: Demon of Greed. A golden skinned man.
Beelzebub: Demon of Gluttony: A demon that appears in a swarm of flies. A raspy voiced, dark eyed man with....wicked eating habits. (Hint: he likes "long pork")
Beheamoth: Demon of Sloth. A large, golem like demon
Azazel: Demon of Pride. A Lion clawed man with golden eyes and expensive clothes.
Asmoedeus: Demon of lust. Father of Lilith. A strong, vampire like demon.