JoshMoshes
DMC Aficionado
Easy, Normal, and Hard are available from the beginning but wait, theres more!
Son of Sparda - Enemies get tougher, attack waves are remixed.
Dante Must Die - Contains the strongest enemies and insane attack waves
Heaven or Hell - The remixed mode, but everyone and everything, including Dante, dies after one hit.
Hell and Hell - The same as above, but only Dante dies after one hit.
http://www.gamesradar.com/dmc-devil-may-cry-four-extreme-difficulty-settings-confirmed-unlockable/
Son of Sparda - Enemies get tougher, attack waves are remixed.
Dante Must Die - Contains the strongest enemies and insane attack waves
Heaven or Hell - The remixed mode, but everyone and everything, including Dante, dies after one hit.
Hell and Hell - The same as above, but only Dante dies after one hit.
http://www.gamesradar.com/dmc-devil-may-cry-four-extreme-difficulty-settings-confirmed-unlockable/