I'm surprised that after all these years, no one has pointed out the similarities between Mistral and Lucia.
As for new enemies, I've been thinking of maybe other demon human hybrids. I don't think Sparda was the only demon who fell for a human.
* Vergil could maybe inherit the Dopplganger system from Dante (he does use a similar ability in his fight with Nero in 5). I don't know what other weapons he could use.
* Alastor and/or Nevan would be fitting for Trish. Apparently, Dante pawned them off to pay his debts but I suppose Trish...
*Superhero fans are way too anal about killing vs not killing.
*Whining about things being too dark and edgy is a bigger cliche than making things be dark and edgy.
*Mortal Kombat might have the best storytelling of any fighting game franchise but improvements still need to be made.
My own ideas.
A game starring Trish and Lady taking on various jobs to keep the DMC building open. Since Mundus is still around, he could serve as a possible villain for them.
Nero and Lucia teaming up to fight remnants of the Order of the Sword who are trying to complete Sanctus’ work. Lucia...
It would depend on how powerful it was. If it is more powerful than the stuff that gave Captain America his powers, it would certainly work.
Power Rangers Lightspeed Rescue had technology developed by normal humans to kill demons. And humans in DMC have been hinted to be a lot more powerful...